HTD Biosystems Inc.

High Throughput Development of Pharmaceuticals

Experiments By Design (EbD) and Multivariate data analysis


Figure shows output from a multivariate experiment design (MED) of a protein formulation.
Input variables are pH, ionic strength, and protein concentration with responses on protein recovery and aggregation.

HTD Biosystems provides courses in Design of Experiments (DOE) to biopharmaceutical companies.
A 2 day course in Experiments by Design (EbD) provides sufficient information to the participants so that they can use DOE effectively in Product Development.
Please contact HTD Biosystems for additional information.
Experiments by Design provides
  • More information with the minimal number of experimental trials.
  • Ranking of critical process variables.
  • Identification of specific interactions between variables.
  • An empirical model from the data that can be used for predicting process scenarios.
  • Presentation of complex data in clear understandable format.
  • Statistical interpretation of the data.
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